We know that around the turn of the Century infant mortality was high. It was 50% in the US and higher in other countries.
We cheated Mother Nature's “Survival of the Fittest” protocol with the discovery of antibiotics, but to what end? What happened to the population we started saving with antibiotics? What happened to the infants and young children that were rescued from diseases and infections that would normally have killed them? After several generations of saving people who would not have survived childhood without intervention, how do they fare as adults?
According to several researchers those (weak) individuals were mostly born with genetic defects in their mitochondria. “Mitochondria are the energy factories that convert the food we eat into the chemical currency that our bodies use to function. Mitochondria are responsible for 90% of the production of energy that our tissues, organs, and bodies require for metabolism. The Textbook of Physiology, states, “It seems almost to be an obvious deduction that the principal function of thyroxine (thyroid hormone) might be simply to increase the number and activity of mitochondria.” ” (1)(55)
“Mitochondrial mutations appear to be largely responsible for metabolic defects at the cellular level, which results in a hypothyroid like condition. Modern thyroid blood tests do not detect this because thyroid hormones levels may be normal, but they are not high enough to stimulate the genetically defective mitochondria into normal activity. The increased basal temperature that results from administering desiccated thyroid is a direct result of enhanced mitochondrial activity.” (1)(59)
The trait for mitochondria is passed from the mother (only) through special DNA that is separate from the 46 chromosomes that dictate humans inherited traits. The father contributes nothing to the inheritance of mitochondria.
Dr. Mark Starr calls the multiple hypothyroid like symptoms resulting from this mitochondrial defect “Type 2 Hypothyroidism.” Type 2 Hypothyroidism therefore cannot be determined by standard Thyroid blood tests since the problem is not hormone related. People with Type 2 Hypothyroidism typically have normal Thyroid blood tests. The term used to refer to defective mitochondria has been “Thyroid Hormone Resistance,” but the name “Type 2 Hypothyroidism” seems to fit this condition a little better.
It seems the average doctor is not equipped to deal with Type 2 Hypothyroidism. They have been wrongly told that all “Thyroid Hormone Resistance” is rare, and always results from a bad gene that occurs in 1 in 50,000 live births. “Usually dominantly inherited, RTH is associated with diverse, heterozygous THRB gene mutations impairing hormone binding and/or transcriptional activity of receptors (3–5).” (2) This information comes from statistics collected in the 1960’s and refers only to “General” Thyroid Hormone Resistance where the Pituitary Gland is resistant to thyroid hormones and Thyroid blood tests show a High TSH reading. In “Peripheral” tissue Thyroid Hormone Resistance the Pituitary Gland is NOT involved and reacts normally to Thyroid Hormones, so Thyroid blood tests will show normal TSH with normal levels of all Thyroid Hormones. “Peripheral Tissue Thyroid Hormone Resistance” is the type of Tissue Resistant Hypothyroidism that Dr. Starr is talking about that presents as “Type 2 Hypothyroidism” where all blood tests are normal. It is NOT rare! Current estimates indicate that at least half the population has it because it is always inherited through the mother.
Remember that 50% mortality at the turn of the Century? Several generations of those saved 50%, and many more saved accumulated annually, have now reproduced this trait consistently for the last 60 years! These people now make up the majority of our population that suffer from Coronary Artery Disease, Diabetes, High Blood Pressure, High Cholesterol, Obesity, Chronic Fatigue, Fertility and Reproductive Problems, Skin Disorders, Liver disease, Gastrointestinal disorders including IBS and Constipation, Fibromyalgia and other Pain disorders, Sleep disorders, Depression and assorted Mental Illness’. Defective mitochondria cause massive problems at the cellular level!
(1) Starr, Mark. Hypothyroidism Type 2: The Epidemic. 4th printing. Published by Mark Starr Trust; 2010
(2) Multiple Authors, American Society for Clinical Investigation, Published in Volume 120, Issue 4, (April 1, 2010);120(4):1345–1354. doi:10.1172/JCI38793
Retrieved from: http://www.jci.org/articles/view/38793
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