Wednesday, February 29, 2012

Peripheral Tissue Thyroid Hormone Resistance


This is what I have.  I take a VERY large dose of T3--100mcg, plus 120mg (2 Grains) of Armour thyroid for a total of 118mcg of T3.  This is a large enough to KILL, or at least cause a lot of harm, to a normal person.  For me this dose is required to keep me alive.  If I don't get it I will drown in Cholesterol (over 400), my body temperature will plummet into a severely sub-normal range (94.6) and I will get severe headaches and various very disabling body aches and pains.  Death from Heart Attack or Stoke will be next.


The information about my condition has been well documented.  It is in both Pharmacy Computer Systems and Hospital Computer Systems. There are many books written about it and it's all over the Internet. There is NO excuse not to know about this if you are a Doctor.  I know because I have checked.  


In my opinion there is NO reason any Doctor should dispute my treatment since it Reversed Coronary Artery Disease, Diabetes and Obesity.  Furthermore, I have been on these high doses for over 4 years. I would be long dead if it wasn't the right treatment.  


What should I do if a Doctor in charge of my care at a Nursing Home refuses to give me my medicine and we have the records to prove he didn't? He literally interfered with my ability to live and has done serious damage to my body's ability to function.  However, they gave me something, it had to be a placebo. So, my question is; did they charge Medicare for the full price of a drug the didn't give me?  What should I do to have this facility investigated?


My Cardiac health and Cholesterol have been perfect for 4 years. Suddenly they are not. We have records from 2 sources to prove my Cardiac and Cholesterol health before I went into the Nursing Home.


"The adverse consequences (of insufficient treatment) include conditions such as fibromyalgia, chronic fatigue syndrome, and liver, and cardiovascular diseases."  http://www.drlowe.com/QandA/askdrlowe/resistnc.htm

Tuesday, February 28, 2012

I have severe fibromyalgia (had)

Sunnier Times for Fibromyalgia Patients--by Dr. John C. Lowe

"Another development that fibromyalgia/thyroid patients may find interesting is the growing movement of self-treating patients. This movement arose from fibromyalgia patients' understandable frustration and impatience with the medical system. In this movement, people take full control of their own health and well-being, not leaving these to medical practitioners. They learn what they need to know, often by taking part in Internet groups of self-treating people who share with others what they've learned. And they put their knowledge to work to improve or recover their health. We at FRF praise the self-reliance of these people, and we'll do everything we can to provide information they need to better understand fibromyalgia and the methods they can use to achieve optimal health."


See the entire post here: http://www.fibromyalgiaresearch.org/

Definition of the difference between "General Thyroid Resistance" and "Peripheral Tissue Thyroid Hormone Resistance"

This is the best explanation about Thyroid Hormone Resistance I have found so far.


Dr. Lowe gave this answer:


When supraphysiologic dosages of thyroid hormone fail to suppress TSH secretion, the patient has "general" resistance to thyroid hormone. This classification of thyroid hormone resistance is different from the one that manifests as fibromyalgia in many patients. The latter classification is termed "peripheral" resistance to thyroid hormone. I will explain the difference between general and peripheral resistance. 


The classification of thyroid hormone resistance is based on whether (1) the pituitary gland and (2) the other tissues of the body (referred to as "peripheral" tissues) are involved in the patient's resistance. In general resistance, both the pituitary gland and the peripheral tissues are partially resistant to thyroid hormone. The patient's thyroid hormone levels are elevated, but his TSH level and his peripheral tissue metabolism are usually normal. Here's why:


In normal functioning of the hypothalamic-pituitary-thyroid axis, when the amount of thyroid hormone in the blood reaches an appropriate level, it then inhibits secretion of TSH by the pituitary gland (this is a normal "feedback" mechanism). But, when the pituitary tissue is resistant to thyroid hormone, much larger amounts are necessary to suppress TSH secretion. When the peripheral tissues are also partially resistant, large amounts of thyroid hormone are needed to "override" the resistance and drive the subnormal metabolism in the periphery to a higher, normal rate. Typically, when these large amounts of thyroid hormone (secreted by a thyroid gland stimulated by large amounts of TSH from a resistant pituitary) finally increase enough to normalize the metabolic rate of the patient's peripheral tissues, the pituitary tissue also finally responds to this amount by reducing its secretion of TSH into the normal range. Thus, patients with general resistance usually have clinically normal peripheral tissue metabolism with high levels of thyroid hormone in the blood, and a normalized level of TSH (finally suppressed only by the high blood levels of thyroid hormone). In this way, the circulating levels of thyroid hormone are kept high enough to override the peripheral tissue resistance (with normalized metabolism) and the pituitary resistance (with normalized TSH). In other words, many general resistance patients appear clinically normal except for the high thyroid hormone levels.


In peripheral resistance to thyroid hormone, only the peripheral tissues are resistant. The pituitary tissue responds normally to a normal amount of thyroid hormone in the blood, and it decreases its TSH output when the blood levels signal that it should do so. Normal blood levels of thyroid hormone, then, properly suppress pituitary gland release of TSH, and keep the circulating TSH levels normal. What's important to realize in this scenario is that the feedback between the pituitary gland and the thyroid gland is normal, and both glands secrete normal amounts of their respective hormones. But the normal thyroid hormone levels are insufficient to override the partial resistance of tissues other than the pituitary--that is the peripheral tissues. As a result, metabolism in the peripheral tissues is subnormal. To speed peripheral tissue metabolism up to normal, the peripheral resistance patient must use large dosages of thyroid hormone. But the effect of these large dosages on the normally responsive pituitary tissue is suppression of the TSH. Thus, secretion of TSH, and its circulating level, are extremely low. 


Unfortunately, most physicians become alarmed when they measure the TSH level in such a patient and find it extremely low. Physicians have been taught that a low TSH level means only one thing in a patient taking thyroid hormone--the dosage is too high and is going to harm the patient. It will take some years for physicians to learn about peripheral resistance to thyroid hormone and to understand the odd test values these patients have when taking effective dosages of thyroid hormone. Patients with peripheral resistance must take TSH-suppressing dosages of thyroid hormone to have normal peripheral tissue metabolism. But there is nothing whatsoever harmful to these patients in having their TSH suppressed by these dosages of thyroid hormone. In fact, it would be harmful for most of them not to take such dosages. The adverse consequences include conditions such as fibromyalgia, chronic fatigue syndrome, and liver and cardiovascular diseases. 
To see the entire post go here:
http://www.drlowe.com/QandA/askdrlowe/resistnc.htm

Dr. Lowe's comments on the Pharmacuetical Companies strong arm tactics.


I came to the same conclusion as Dr. Lowe and I stated it in "Roadblocks to the Cure" at the beginning of this blog, but he is far more eloquent than I am!   So, here it is.


"I learned early during the last 16 years that the endocrinology specialty's judgment is corrupted by financial inducements from drug companies that profit from the TSH test and T4 replacement. All those years ago, my intention was to help revise the often harmful standard of care imposed by the endocrinology specialty for commercial rather than scientific reasons.  After careful consideration in the last several years, however, I realized that the specialty has its heels dug in; it's clear to me that the specialty won't volitionally rehabilitate itself into a rational, scientific, ethical, and respectable medical specialty (endocrinology).


Rather than rehabilitate, to this day, the specialty practices thuggery on a par with that of traditional organized crime. It does so by intimidating and persecuting clinicians who fail to cooperate in restricting their patients to T4 replacement—an often ineffective and harmful approach to therapy that's hugely profitable to Big Pharma and, by quid pro quo, to the specialty itself.


The well-intending persecuted clinicians are guilty of recognizing that T4 replacement doesn't work for and harms many patients. And they are guilty of having the courage to abide by the Hippocratic oath in using thyroid hormone therapies that get their patients well. 


The thuggery of the specialty is in highly active gear. We know this because regularly, clinicians contact us and tell us of actions being taken against them by medical regulatory boards. Invariably, the action involves  testimony against the clinicians by members of the endocrinology specialty or affiliates of theirs.


And what is the ultimate consequence of these actions against so many well-intended clinicians? Patients who need safe and effective thyroid hormone therapy are restricted to T4 replacement—an approach that published studies clearly show to be ineffective and harmful for many patients.


It seems that most every community has members of the endocrinology specialty who function as thugs. They act as enforcers of the command that clinicians use only TSH testing and T4 products. These thug endocrinologists file complaints against noncompliant clinicians. Then they testify against the clinicians before regulatory boards and courts and walk away scot-free after giving scientifically-false testimony in courts of law and other legal venues.


Experience tells me that the endocrinology specialty won't relent—not until it's forced to do so, probably by class action law suits and by forcible complaints for violations of medical ethics to purveyors of medical regulatory boards. To me, the final solution lies in the education of patients, clinicians, and legislators; legislation to disempower the endocrinology specialty from further harm to patients, clinicians, and the public welfare; and litigation against the specialty and its corporation supporters.


The force of unforgiving corruption by the specialty and its affiliates has long loomed over me and my medical colleagues. Because of this, at the beginning of 2010, I decided to preemptively remove from my back the target known as "licensed clinician." Having divested myself of that particular easy target, I'm now free to communicate with people (patients, their loved ones, and their clinicians) simply as a clinical researcher, educator, and natural health advocate."  


Dr. John C. Lowe is a fibromyalgia, thyroid, and metabolism researcher. As Director of Research for the Fibromyalgia Research Foundation, he has spearheaded the scientific study of two related topics: the metabolic causes of fibromyalgia, and the relief of fibromyalgia symptoms through the treatment approach he developed and named "metabolic rehabilitation."  see more here: http://www.drlowe.com/