Well so far no luck in finding someone to treat me for my Peripheral (tissue) Thyroid Hormone Resistance. Pac Med failed to have someone who has even heard of it and the Poly Clinic had someone who has heard of it but has no idea how to manage, or diagnose it. The UW is pretending it doesn’t exist. Probably because they receive lots of money for Drug research from pharmaceutical companies.
http://sop.washington.edu/porpp
Thyroid Hormone Resistance is called Type 2 Hypothyroidism and it is claimed to be an untreated epidemic in the US.
"blood tests do not detect Type 2 hypothyroidism." "The pervasiveness of Type 2 hypothyroidism has yet to be recognized by mainstream medicine but is already in epidemic proportions."
http://www.type2hypothyroidism.com/Type1VsType2.html
Thyroid hormones transport essential Iodine to all cells of your body (called Iodine uptake). Thyroid Hormones are made by the thyroid gland and are called: T4, T3, T2, T1, and calcitonin. The thyroid gland also produces Reverse T3 (RT3) to regulate T3 uptake. The ratio of RT3 to T3 is about 60:40. Thyroid hormone T3 is the active hormone in metabolism regulation. The storage hormone T4 is converted to the usable hormone T3 in the liver. The other hormones--T2, T1 and Calcitonin--help regulate the effects of T3 on the body.
Here is what Dr. Jarvis has to say about the Halogen's, one of which is Bromine, and their effect on displacing Iodine in the body: "There is a well-known law of halogen displacement. The halogen group is made up as follows:
Halogen’s Relative Atomic Weight (found primarily in)
Fluorine 19. (drinking water and dental products)
Chlorine 35.5 (drinking water)
Bromine 80. (agricultural pesticides)
Iodine 127. (Kelp and Sea Salt)
The critical activity of any one of these four halogens is in inverse proportion to its atomic weight. This means that any one of the four can displace the element with a higher atomic weight, but cannot displace an element with a lower atomic weight. For example, fluorine can displace chlorine, bromine and iodine because fluorine has a lower atomic weight than the other three. Similarly, chlorine can displace bromine and iodine because they both have a higher atomic weight. Likewise, bromine can displace iodine from the body because iodine has a higher atomic weight. But a reverse order is not possible. A knowledge of this well-known chemical law brings us to a consideration of the addition of chlorine to our drinking water as a purifying agent. We secure a drinking water that is harmful to the body not because of its harmful germ content but because the chlorine content now causes the body to lose the much-needed iodine."
http://www.jcrows.com/hypothyroidism.html
US Gov medical site: "A metabolic basis for fibromyalgia and its related disorders: the possible role of resistance to thyroid hormone."
http://www.ncbi.nlm.nih.gov/pubmed/12888300
"Fibromyalgia, Hypothyroidism and the Theories of Dr. John Lowe"
http://thyroid.about.com/cs/fibromyalgiacfs/a/drlowe.htm
"In some patients, the inadequate tissue regulation by thyroid hormone results from cellular resistance to thyroid hormone. In others, the inadequate regulation results from a thyroid hormone deficiency. So, when I refer to fibromyalgia, I'm referring to a certain set of symptoms and signs of too little thyroid hormone regulation of tissues."
http://www.thyroid-info.com/articles/drlowefms.htm
"Some experts believe that like most cases of hypothyroidism, fibromyalgia is also autoimmune in nature. Others believe that fibromyalgia may be one manifestation of an underactive metabolism – hypometabolism – and is therefore one variation on thyroid dysfunction."
http://thyroid.about.com/cs/fibromyalgiacfs/a/fibrothyroid.htm
FYI - There are a several million people on the web complaining about the lack of good diagnosis and treatment of Hypothyroidism and its related Adrenal issues, which I suffer from as well.
This next site, The National Academy of Hypothyroidism is the best one I have found that explains how the Thyroid Hormones get to their intended location. It is NOT by diffusion as was previously thought.
“Changes in pituitary conversion of T4 to T3 are often opposite of those that occur in the liver and kidney under similar circumstances. The presence of this pathway of T3 production indicates that the pituitary can respond independently to changes in plasma levels of T4 and T3…Given these results, it is not surprising that a complete definition of thyroid status requires more than the measurement of the serum concentrations of thyroid hormones. For some tissues, the intracellular T3 concentration may only partially reflect those in the serum. Recognition that the intracellular T3 concentration in each tissue may be subject to local regulation and an understanding of the importance of this process to the regulation of TSH production should permit a better appreciation of the limitations of the measurements of serum thyroid hormone and TSH levels (148).”
http://nahypothyroidism.org/deiodinases/9
Book: Lowe, J.C.: The Metabolic Treatment of Fibromyalgia. Boulder, McDowell Publishing Co., 2000. The only definitive test I have found for Peripheral Tissue Thyroid Hormone Resistance (it's listed in all the pharmacy and hospital computers by the way) is "TSH suppressed to Zero, and patient can take 125mcg of, T3, liothyronine and it doesn't hurt them, but makes them better," as referred to in "The Metabolic Treatment of Fibromyalgia" by Dr. John C. Lowe.
http://www.goodreads.com/book/show/679258.The_Metabolic_Treatment_of_Fibromyalgia
"At a dose of 125 mcg per day, she began feeling better, her skin and hair improved, and she lost 20 pounds over two months." Dr. Jacobs
http://www.neuroendocrinology.org/thyroid-hormone-resistance.html
Book: "In Dr. Starr's description of Type 2 Hypothyroidism, he presents overwhelming evidence showing a majority of Americans suffer this illness, which is due to environmental and hereditary factors." Mark Star MD
http://www.ei-resource.org/related-conditions-books/thyroid-disorders/hypothyroidism-type-2:-the-epidemic/
I have talked to Alan R. Jacobs, M.D., neuroendocrinologist, Mark Star MD, and several fibromyalgia clinics that take Cash only. Apparently they are all a step ahead of the endocrinologists that I have already seen at Pac Med and the Poly Clinic who can't help me. There are also several Naturopaths that are treating this disorder, but I am curious as to why they all take Cash only, or very limited insurance in some cases? Unfortunately, I have no money due to the lifelong struggle with this disorder that destroyed my life.
Because of what I have learned from my own intensive research in an effort to save my own life, I have come to the conclusion that this is an area of medicine (thyroid hormone resistance - Type 2 hypothyroidism) that is grossly ignored, and very misunderstood.
It is important to note that there are 3 types of Thyroid Hormone Resistance. 'General' Thyroid Hormone Resistance (RTH) is the one that has been identified as most often (85% of the time) having a Genetic cause, however there is also 'Peripheral" (tissue) Thyroid Hormone Resistance (PRTH), and Partial 'Peripheral" (tissue) Thyroid Hormone Resistance (partial PRTH). The statistics of 1 in 50,000 live births (less than 10,000 people using 2010 population statistics) are about the prevalence of 'General' Thyroid Hormone Resistance and the numbers are from the 1960's. This informations seems to be what the community of practitioners is relying on. Yet, current information indicates there may be as many as half the US population affected by 'Peripheral' Thyroid Hormone Resistance and it is genetic, but may also be environmental! So, not enough attention is being paid to this phenomena.
"Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established."
http://www.uniprot.org/uniprot/P10828
"Resistance to thyroid hormone (RTH) is an uncommon disorder, characterized by elevated circulating thyroid hormones with non-suppressed thyrotropin (TSH) levels, reflecting resistance within the hypothalamic-pituitary-thyroid axis but variable refractoriness to hormone action in peripheral tissues (2). Usually dominantly inherited, RTH is associated with diverse, heterozygous THRB gene mutations impairing hormone binding and/or transcriptional activity of receptors (3–5). In addition, mutant receptors inhibit the action of their wild-type counterparts in a dominant-negative manner when they are coexpressed (6, 7). The clinical phenotype of RTH is variable: most subjects are either asymptomatic or have nonspecific symptoms and are deemed to be in a compensated euthyroid state termed generalized RTH (GRTH); in contrast, a subset of affected individuals can exhibit some clinical features of hyperthyroidism, suggesting greater central or pituitary RTH (PRTH) than in peripheral tissues. Although imprecise, this clinical distinction may remain useful in the management of the disorder (8). The basis of and mechanisms underlying variable tissue resistance in RTH are not fully understood."
http://www.jci.org/articles/view/38793
I need someone who understands the nature of Peripheral Thyroid Hormone Resistance and is willing to treat me with the supraphysiologic doses of liothyronine (125mcg) I need, according to my symptoms, to help me stay alive and well. Someone who will listen to me, and provide assistance in the management of this tricky disorder and the Adrenal Fatigue that goes with it. Preferably someone I can see in person and takes my insurance. (I have plenty of offers for Cash.)
In my research I came across a lot of evidence indicating that Insulin Resistance is strongly linked to Thyroid Hormone Resistance in obese diabetics. These two conditions may have the same cause.
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